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Why There's New Hope About Ending Blindness
Lewis again sees the lights of her Christmas tree. Zrenner describes a . call it simply a patch. That patch's chassis, made of the same stuff used to coat wiring for pacemakers and neural implants, is wafer thin, bottle shaped, and the size of a fat
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VHCB2901: Features: -Buoyant Little Christmas collection. -Machine stitched. -Soft marzipan wool base fabric. -Charming arrangement of rick batter and pom-pom lace encircling hearts and cross stitches with rice stitch accents all in cherry red and chestnut. -3 Light wooden buttons and loops to fixed skirt around tree. -Wool and felt. Dimensions: -Trimmed with 0.5 chestnut felt binding. -Reverses to chestnut felt with a 5 diameter circle. Overall Height - Top to Bottom: -50. Overall Width - Side to Side: -50. Overall Product Weight: -0.75 lbs.
Christmas characters and food, Christmas-linked holidays and music, Santa Claus and traditions. Related to Annunciation, Incarnation; Crucifixion; Advent, the four weeks preceding Christmas; and the period between the day after Thanksgiving and the Sunday after New Year”s Day, the American holiday season. Christmas or Christmas Day is a holiday celebrating the birth of Jesus, the central figure of Christianity. Aspects of celebration may include gift-giving, Christmas trees, display of Nativity sets, church attendance, the Father Christmas/Santa Claus myth, and family gatherings. Users of the Gregorian calendar observe the holiday on December 25. Some Eastern Orthodox Churches celebrate on December 25 by the Julian calendar, which currently corresponds to January 7 on the Gregorian...
Highlighted by more than one thousand photographs, a richly illustrated guide to holiday decorating from two celebrity designers features an innovative collection of special suggestions and creative tips on everything from Christmas lights to ornaments and trimmings, to help readers celebrate the holidays in a colorful way.
From the day Christian Guardino was born, his mother, Elizabeth, knew that something was wrong with his eyes. One eye turned inward. When she fed him, instead of gazing up at her, Christian would stare at the brightest light around—a lamp if they were indoors, the sun if they were out. The first eye doctor who saw Christian grimly referred the family to a specialist at New York’s Mount Sinai Hospital. The specialist performed an electroretinogram (ERG), a procedure in which a tiny electronic sensor placed on the eye measures the retina’s response to bursts of light. A healthy retina will respond by firing an electrical signal down the optic nerve that produces, on the ERG machine’s printout, a deep valley followed by a tall peak. Christian’s ERG produced no such thing: only squiggles, ill-formed and weak. Christian did need a cane, and his mother’s guiding hand, when in 2012, at age 12, he first visited a clinic run by the University of Pennsylvania’s Scheie Eye Institute. Yet this January he walked through the institute’s main building cane free and seemingly fearless. Joking and chatting, the teen led a klatch of Ph. D. ’s, M. D. ’s, lab techs, and me through the airy lobby. ” he said as we neared the building’s exit—for before us an enormous revolving door turned its huge blades. His mother was some distance behind. Christian neither stopped nor paused. He walked calmly through the opening of the spinning wedge of steel and glass and held his pace as one glass wall closed behind him and another smoothly swung out of his way. Ahead of her, Christian walked with Jean Bennett, whose lab at Penn produced the gene-laced fluid that gave Christian sight. “It happened so fast,” Elizabeth said. Just three days after his first eye was treated, Christian could see her. “I went from wondering if my son would ever know what I looked like to … well, this,” she said, gesturing at him walking unaided. “It’s like a miracle. Christian’s miracle was hard-won. It rose from 20 years of unrelenting work by Bennett and her collaborators, who identified the genetic mutation that crippled Christian’s retina, then figured out how to sneak a good copy of that gene into his eye. Bennett started trials for the therapy merely hoping “that we could detect some hint of improvement. ” Nine years later she is astonished that it seems to have worked so well. Bennett takes care not to aggrandize her work or underplay the obstacles to further progress. Yet the gains so far for Christian and other patients give Bennett guarded hope that this basic gene-replacement approach might work for other forms of blindness. She and others believe that variations on her technique might soon help doctors find and fix similar genetic defects early enough—perhaps even in utero—to reverse or prevent eye damage. Within roughly the past decade, efforts in two other areas, stem cells and biomedical, or “bionic,” implants, have also given at least some sight to people previously sightless. Stem cells—cells in early stages of development, before they differentiate into the building blocks of eyes, brains, arms, and legs—show increasing promise to replace or revive the failing retinal cells that underlie many causes of blindness. And the first generation of bionic retinas—microchips that replace failed retinal cells by collecting or amplifying light—is bringing a low-resolution version of sight to people who for years saw nothing. Some advocates and fund-raisers are suggesting so. Businessman Sanford Greenberg , who lost his sight to glaucoma while in college, has founded End Blindness by 20/20 , which offers three million dollars in gold to the person or persons who... The National Eye Institute, one of the U. S. National Institutes of Health, is aggressively funding eye research with large awards from an Audacious Goals Initiative. The World Health Organization and the International Agency for the Prevention of Blindness’s Vision 2020 initiative states a goal of “eliminating avoidable blindness by 2020. ” Meanwhile many a breathless media story about work like Bennett’s... Bennett has seen countless gene-therapy efforts fail. In a recent paper she bluntly lists the daunting obstacles to expanding her therapeutic approach even to other genetic causes of LCA. For example, the gene she inserted into Christian’s eye, known as RPE65,